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https://repositorio.museu-goeldi.br/handle/mgoeldi/2616| metadata.dc.type: | Artigo de Periódico |
| Title: | Chemical composition, antioxidant activity, anti-inflammatory andneuroprotective effect of Croton matourensis Aubl. Leaves extractsobtained by supercritical CO2 |
| Other Titles: | Composição química, atividade antioxidante, efeito antiinflamatório e neuroprotetor de Croton matarensis Aubl. Extratos de folhas obtidos por CO2 supercrítico |
| metadata.dc.creator: | Bezerra, Fernanda Wariss Figueiredo Andrade, Eloisa Helena de Aguiar |
| metadata.dc.description.resumo: | Croton matourensis leaves extract was studied for its anti-inflammatory and neuroprotective effects after experimental stroke. The study investigated the extracts obtained with supercritical CO2(SC−CO2) under different operational conditions of temperature (40 and 50◦C) and pressure (100−400 bar), assessing their global yield isotherms, chemical composition and antioxidant activity, in comparison to extracts obtained by hydrodistillation (HD) and n-hexane (HE). The highest yields were obtained with SC−CO2 at 50◦C and 400 bar (5.60 ± 0.06 %) and in the HE (5.73 ± 0.26 %). The major compound found in HD and HEwas linalool (35.26 and 69.98 %, respectively), whereas in SC−CO2 extraction was larixol (24.88–50.57 %). The extracts showed high total phenolic contents, total flavonoids and antioxidant activity with maximum percent inhibition of DPPH radical of 83.26 ± 0.58 %. The treatment suggests a potential anti-inflammatory and neuroprotective effect, showing reduction in the injury of the animals treated with the SC−CO2 extract. |
| Abstract: | O extrato de folhas de Croton matarensis foi estudado por seus efeitos antiinflamatórios e neuroprotetores após acidente vascular cerebral experimental. O estudo investigou os extratos obtidos com CO2 supercrítico (SC−CO2) sob diferentes condições operacionais de temperatura (40 e 50◦C) e pressão (100−400 bar), avaliando suas isotermas de rendimento global, composição química e atividade antioxidante, em comparação com extratos obtidos por hidrodestilação (HD) e n-hexano (HE). Os maiores rendimentos foram obtidos com SC−CO2 a 50◦C e 400 bar (5,60 ± 0,06%) e no HE (5,73 ± 0,26%). O principal composto encontrado na HD e HE foi o linalol (35,26 e 69,98%, respectivamente), enquanto na extração SC-CO2 foi o larixol (24,88–50,57%). Os extratos apresentaram elevado teor de fenólicos totais, flavonóides totais e atividade antioxidante com percentual máximo de inibição do radical DPPH de 83,26 ± 0,58%. O tratamento sugere potencial efeito antiinflamatório e neuroprotetor, mostrando redução da lesão dos animais tratados com extrato SC-CO2. |
| Keywords: | Croton matourensis Aubl. Supercritical extraction Larixol Antioxidant activity Neuroprotection Anti-inflammatory effecta |
| metadata.dc.subject.cnpq: | CNPQ::CIENCIAS BIOLOGICAS::BOTANICA |
| metadata.dc.language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Museu Paraense Emílio Goeldi |
| metadata.dc.publisher.initials: | MPEG |
| Citation: | BEZERRA, Fernanda Wariss Figueiredo ET AL. Chemical composition, antioxidant activity, anti-inflammatory andneuroprotective effect of Croton matourensis Aubl. Leaves extractsobtained by supercritical CO2. The Journal of Supercritical Fluids, v. 165, p. 104992, 2020. |
| metadata.dc.rights: | Acesso Aberto |
| URI: | https://repositorio.museu-goeldi.br/handle/mgoeldi/2616 |
| Issue Date: | 21-Jul-2020 |
| Appears in Collections: | Botânica - Artigos Publicados em Periódicos |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Chemical composition, antioxident .....pdf | 1,86 MB | Adobe PDF |  View/Open |
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